Studies for the synthesis of marine natural products.
نویسندگان
چکیده
The process of allylic transposition in S(E)' reactions is a significant construct for synthesis. The flexibility of a variety of allylation strategies provides for the rational design of pathways to a diverse array of complex targets. Our recent studies of S(E)' reactions will examine issues of stereoselectivity and efficiency in the context of applications toward the synthesis of marine natural products such as the xenicane diterpenes, which feature the strained E-cyclononene ring system, and peloruside A, a 16-membered macrocyclic lactone.
منابع مشابه
Persian Gulf Marine Sponge/I2: An efficient natural catalyst for quinoline synthesis
A natural and efficient method has been developed for the synthesis of quinoline derivatives in good-to-high yields, from various aryl aldehydes, amines and phenyl acethylene, using marine sponge/I2 as a green catalyst
متن کاملRecent heterocyclic compounds from marine invertebrates: Structure and synthesis
A large variety of unique heterocyclic natural marine products, without terrestrial counterparts, have been isolated from marine invertebrates, mainly sponges, ascidians, and soft corals. Many of these compounds display interesting biological activity. In this review, we report our recent studies on nitrogen-containing heterocyclic compounds (“alkaloids”), as well as some containing sulfur and ...
متن کاملRecent Advances in the Isolation, Synthesis and Biological Activity of Marine Guanidine Alkaloids
Marine organisms are prolific resources of guanidine-containing natural products with intriguing structures and promising biological activities. These molecules have therefore attracted the attention of chemists and biologists for their further studies towards potential drug leads. This review focused on the guanidine alkaloids derived from marine sources and discussed the recent progress on th...
متن کاملThiazole and Oxazole Alkaloids: Isolation and Synthesis
Thiazoles, oxazole and their corresponding reduced derivatives, thiazolines and oxazolines, are found in marine sources exhibiting significant biological activities. The isolation, synthetic, and biological studies of these natural products, covering literature from January 2007 to June 2010, are summarized.
متن کاملNew One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds
There are several avenues by which promising bioactive natural products can be produced in sufficient quantities to enable lead optimization and medicinal chemistry studies. The total synthesis of natural products is an important, but sometimes difficult, approach and requires the development of innovative synthetic methodologies to simplify the synthesis of complex molecules. Various classes o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Pure and applied chemistry. Chimie pure et appliquee
دوره 81 2 شماره
صفحات -
تاریخ انتشار 2009